A Fast, Effective Option When Traditional Treatments Fail
Depression can make life feel heavy, slow, and hopeless. And for many people, antidepressants just don’t work. In fact, about 1 in 3 people with depression don’t get better with standard medications.
That’s why newer, faster-acting treatments like ketamine are changing the game. In cities like Phoenix, Gilbert, and Glendale, one option gaining popularity is Intramuscular (IM) Ketamine Injections—a safe and powerful way to quickly relieve symptoms of depression, even when nothing else has worked.
If you’re feeling stuck, this post will help you understand what IM ketamine therapy is, how it works, who it’s for, and how it compares to other options like IV infusions or Spravato®.
What Are IM Ketamine Injections?
IM stands for intramuscular—meaning the ketamine is injected directly into your muscle, usually in your arm or leg. The treatment is done in a medical setting by trained professionals and typically lasts about 30 to 60 minutes from start to finish.
The goal of IM ketamine therapy is to reduce symptoms of major depressive disorder, including suicidal thoughts, anxiety, and emotional numbness.
Unlike most antidepressants that target serotonin, ketamine works on the glutamate system—helping your brain rebuild damaged connections and process emotions more clearly.
Why Choose IM Ketamine Over IV or Spravato®?
All forms of ketamine offer fast relief, but IM injections come with unique advantages:
- Faster and simpler than IV infusion
- No need for an IV line or infusion pump
- Dosing can be adjusted quickly based on response
- Sessions are shorter and less expensive
- Ideal for patients who want fast results in fewer steps
Compared to Spravato®, IM injections aren’t FDA-approved for depression, so they’re considered off-label—but many clinics use them with great success. Unlike Spravato®, insurance often doesn’t cover IM ketamine.
What Does the Science Say?
Research on IM ketamine is still growing, but early studies show strong results. In clinical settings:
- Up to 70% of people with treatment-resistant depression feel better after a few sessions
- Many notice relief within hours to days, rather than weeks
- The effects tend to last longer when combined with therapy or follow-up treatments
According to the National Library of Medicine and Yale researchers, ketamine helps rewire the brain, increase neuroplasticity, and reduce harmful thinking loops that fuel depression.
What Does Treatment Look Like?
A typical IM ketamine session at a clinic like Bella Vida TMS includes:
- Medical evaluation to confirm ketamine is safe for you
- Injection into a large muscle like the thigh or upper arm
- Monitoring by medical staff for 45–60 minutes
- Post-treatment rest, as most people feel tired afterward
- Ride home required—you won’t be able to drive that day
Most patients start with 2 sessions per week for 2–3 weeks, then shift to a maintenance plan.
How Will I Feel During and After?
Many people describe the experience as peaceful or slightly “floaty.” You may feel detached from your body or surroundings. This effect, called dissociation, wears off quickly and can actually help you process stuck emotions.
After the session, some people feel clear and uplifted. Others feel sleepy and need to rest.
Common side effects include:
- Mild dizziness
- Fatigue
- Nausea
- Brief increase in blood pressure
- Emotional sensitivity after sessions
Is It Safe?
Yes—when done under supervision in a licensed clinic, IM ketamine injections are safe for most adults with depression. You’ll be screened for heart health, mental stability, and any substance use history.
You should not use ketamine if you:
- Have uncontrolled high blood pressure
- Have active psychosis or schizophrenia
- Have a history of substance abuse without stability
- Are pregnant or nursing
At Bella Vida TMS, safety is always our top priority. We evaluate each patient carefully and monitor every session from start to finish.
How Much Does It Cost?
Because IM ketamine for depression is off-label, most insurance plans do not cover it. However, it’s often more affordable than IV infusions.
- Single sessions usually cost between $300–$500
- Some clinics offer discounted packages
- Financing and payment plans may be available
If you’re looking for insurance-covered ketamine treatment, consider Spravato®, the FDA-approved nasal spray. Bella Vida TMS offers Spravato® and can verify your coverage at no cost.
What About TMS?
Not everyone is comfortable with medication. That’s where TMS (Transcranial Magnetic Stimulation) can be a great alternative.
TMS is:
- FDA-approved
- Drug-free and non-invasive
- Covered by most insurance plans
- Done in-office with no downtime
If you’re unsure whether IM ketamine is right for you, our team can walk you through TMS, Spravato®, or other care options—all in one place.
Final Thoughts
Intramuscular ketamine injections are a powerful new option for people who feel like they’ve tried everything. They’re fast, effective, and help people regain control when depression won’t let go.
At Bella Vida TMS, we’re here to help you explore your options with care, science, and compassion. Whether you’re interested in IM ketamine, Spravato®, or TMS, we’ll help you build a personalized plan that gives you the best chance at real, lasting relief.
References
- National Institute of Mental Health (NIMH) – Depression Overview
https://www.nimh.nih.gov/health/topics/depression - Harvard Health Publishing – Ketamine for major depression: New tool, new questions
https://www.health.harvard.edu/blog/ketamine-for-major-depression-new-tool-new-questions-2019052216673 - Yale School of Medicine – Ketamine for Depression
https://medicine.yale.edu/news-article/ketamine-offers-hope-for-people-with-severe-depression/ - Journal of Affective Disorders – Rapid antidepressant effects of ketamine in major depression
https://www.sciencedirect.com/science/article/abs/pii/S0165032711001562 - Stanford Medicine – Ketamine Treatment for Depression
https://med.stanford.edu/psychiatry/patient_care/ketamine.html - PubMed – National Library of Medicine – The use of intramuscular ketamine in treatment-resistant depression
https://pubmed.ncbi.nlm.nih.gov/26559313/ - Mayo Clinic – Ketamine therapy: Is it a safe option for depression?
https://www.mayoclinic.org/tests-procedures/ketamine-infusion/about/pac-20417354
